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Latest News
10.15.24 Ulrich Keyser seminar We were excited to have Prof. Ulrich Keyser (Cambridge U.) join us for a virtual department seminar titled "Native RNA detection using nanopores: Isoforms, RNA modifications, and disease diagnostics”. His work is always top-notch and inspiring and he was kind enough to spend some extra time in separate discussion with with our lab on the finer points of nanopore measurement, etc. Thank you, Uli!
08.26.24 Welcome Noor Refaqat We welcome our newest lab member, Noor Refaqat! Noor joins the BME Master's program, fresh from graduating from the University of Illinois in Urbana-Champaign. She will be working on regenerative medicine research, focusing on the adaptive immunity chip project.
08.16.24 Congratulations, Dr. Abu Jalboush! Congratulations to Sara who successfully defended her dissertation, titled "Application of solid-state nanopore technology to the translational analysis of oxidative damage through quantification of 8-oxo-7, 8 dihydroguanine in genomic DNA". She will be staying with us briefly to perform some additional experiments and to finish off several papers reporting this work. Great work, Sara!
07.27.24 Welcome visiting scientist Joining the lab this week is Dr. Karen Mifsud, a lecturer in Behavioral Genetics from the University of Bristol Veterinary School. Dr. Mifsud is visiting us to learn more about or hyaluronan analysis techniques and to initiate collaborative work. Welcome!
07.16.24 Dorothea wins prizes at the Proteoglycan GRS/GRC Dorothea had an outstanding showing at the Proteoglycan conference! After being awarded a travel grant to attend, she earned top honors for Most Outstanding Talk at both the Gordon Research Seminar and Gordon Research Conference portions of the meeting. In addition to all the great research and people, this was a huge honor. Congratulations!
06.07.24 From Solid State to Biophysics XI Adam attended and presented at the biannual From Solid State to Biophysics conference in Cavtat, Croatia! Lots of great people from the nanopore community and beyond in attendance, a fantastic program and array of activities, and - as always - a beautiful venue. Thank you to all the organizers, but especially Slaven Garaj and Aleksandra Radenović for support after a computer issue. Looking forward to next time!
04.08.24 Author corrections We identified a small clerical error in our 2016 paper entitled "Quantifying mammalian genomic DNA hydroxymethylcytosine content using solid-state nanopores" in which a variable was misplaced in an expression. Results were unaffected, and the correction was just published. Unfortunately, our 2021 paper "Solid-state nanopore analysis of human genomic DNA shows unaltered global 5-hydroxymethylcytosine content associated with early-stage breast cancer" used the expression with the error and this time results were affected, although the conclusions were not. That correction has also just been published. We regret any difficulties this has caused!
03.07.24 New paper out now in ACS Sensors Our latest paper was published online today in ACS Sensors, describing improvements to the selective solid-state nanopore assay realized by implementing a polyhistidine-tagged monovalent streptavidin (hMS) protein. A major innovation here was the hMS reagent itself, which is expressed in high purity and yield. Congrats to co-lead authors Sara, Ian, and Komal and cheers to our collaborators in biochemistry without whom the expression would not have been possible!
02.12.24 Dorothea wins ISHAS Research Grant Congratulations to Dorothea who has been awarded a Research Grant through the International Society for Hyaluronan Sciences! The funds will be used to support the incorporation of additional quantitative inflammation-tagged (heavy-chain) HA in our ongoing study of HA in disease models. This work will be a new collaboration with Aaron Petrey (Utah) and a continuation of work with Tony Day (U Manchester) and Paul DeAngelis (Oklahoma Health Sciences)
01.12.24 Latest paper published in Analytical Chemistry Our newest work on nanopore analysis of heavy-chain modified hyaluronan in physiological biofluids is now published in Analytical Chemistry. This paper is by lead author Dorothea Erxleben and in collaboration with our many great colleagues at U Manchester, Oklahoma Health Sciences, Duke Med, Cornell Vet, and Aarhus.
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